Electroencephalographic and Behavioral Effects of 4-phosphoryloxy N,n-dimethyltryptamine (psilocybin) on the New Zealand Albino Rabbit
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چکیده
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منابع مشابه
The pharmacology of psilocybin.
Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is the major psychoactive alkaloid of some species of mushrooms distributed worldwide. These mushrooms represent a growing problem regarding hallucinogenic drug abuse. Despite its experimental medical use in the 1960s, only very few pharmacological data about psilocybin were known until recently. Because of its still growing capacity for abuse...
متن کاملEffects of psilocybin on time perception and temporal control of behaviour in humans.
Hallucinogenic psilocybin is known to alter the subjective experience of time. However, there is no study that systematically investigated objective measures of time perception under psilocybin. Therefore, we studied dose-dependent effects of the serotonin (5-HT)2A/1A receptor agonist psilocybin (4-phosphoryloxy-N, N-dimethyltryptamine) on temporal processing, employing tasks of temporal reprod...
متن کاملDreams and Psychedelics: Neurophenomenological Comparison and Therapeutic Implications
BACKGROUND A resurgence of neurobiological and clinical research is currently underway into the therapeutic potential of serotonergic or 'classical' psychedelics, such as the prototypical psychedelic drug lysergic acid diethylamide (LSD), psilocybin (4-phosphoryloxy-N,Ndimethyltryptamine), and ayahuasca - a betacarboline- and dimethyltryptamine (DMT)-containing Amazonian beverage. The aim of th...
متن کاملImprovements to the Synthesis of Psilocybin and a Facile Method for Preparing the O-Acetyl Prodrug of Psilocin
An improved procedure to accomplish the O-phosphorylation of 4-hydroxy-N,N-dimethyltryptamine (psilocin 5) is reported that utilizes reaction between the O-lithium salt of 5 and tetra-Obenzylpyrophosphate. The O-benzyl groups were removed by catalytic hydrogenation over palladium on carbon to afford N,N-dimethyl-4-phosphoryloxytryptamine (psilocybin, 1). In view of difficulties encountered in t...
متن کاملBiosynthesis of Psilocybin Part II*, Incorporation of Labelled Tryptamine Derivatives
The biosynthesis of psilocybin has been investigated by feeding labelled precursors to Psilocybe cubensis. The following specifically labelled compounds were synthesized: psilocin-H, 4hydroxytryptamine-, N,N-dimethyltryptamine-C and --H, N-methyltryptamine-C-H and DLtryptophan-H. A number of other indoles were labelled by acid catalyzed exchange in tritiated water. The experimental data suggest...
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